University of Calgary

Andre Buret

  • Professor
  • Professor
  • Integrative Cell Biology

Research Interests

Similar inflammatory, immunologic, and pathophysiologic events characterize disease processes at mucosal sites such as the intestine and the lung. Critical issues to this research area include understanding the role of immune cells and mediators in the production of disease. The overall aim of my research is to define microbial-epithelial and immune cell interactions in these systems, and how such interactions may affect gastrointestinal and pulmonary physiology, responsiveness, and inflammation, in an attempt to develop novel therapeutic strategies.

Graduate Students

Amat, Christina MSc Effects of Giardia on intestinal mucins

Awards

2019: Stoll-Stunkard Memorial Lectureship Award, American Society of Parasitologists, an award that “is to honor someone whose prominence in basic research is evident, and whose research might enhance investigations on parasites, hence fostering cross-fertilization of ideas and approaches”

2018: Great Supervisor Award, presented by the Faculty of Graduate Studies, University of Calgary. 

2018: 2018 Public Education Award (Host-Parasite Interactions Program), Canadian Society of Zoologists

2016: Students’ Union Teaching Excellence Award nomination, University of Calgary2013: Achievement in Innovation recognition plaque (“to recognize contributions to the growth of Science and Technology”), Innovate Calgary2013: Honorary Professorship, free Old Herborn University (Germany)

2013: Inducted a member of the Order of the University of Calgary (“to recognize exemplary service to the university and the community (local, provincial, and international), international stature as a scientist, and award-winning teaching”).

2012: Honoured Athletic Leadership Award (karate), City of Calgary Booster Club

2012: Killam Annual Professor Research Award

2012: NSERC CREATE award 

2011: Faculty of Science Award for Excellence in Research, University of Calgary

2008: Robert A. Wardle Medal, Canadian Society of Zoologists, for outstanding contributions to Parasitology research on the national and international scenes

2008: Endeavour Research Fellowship Award, Government of Australia, for research and innovation

2007: Research Excellence Award, Canadian Association of Gastroenterologists

2007: Synergy Award for collaborative research and innovation, Natural Sciences and Engineering Research Council of Canada (NSERC) 

2007 - Research Excellence Award, Canadian Association of Gastroenterology

2006 - NSERC Synergy Award for collaborative research and innovation, Univ. of Calgary nominee

2005 - Students' Union Teaching Excellence Award Honorable Mention Winner

2003 - University of Calgary Graduate Students' Association Teaching Excellence

Selected Publications

Google Scholar Link

FISHER C, BEATTY JK, DUQUETTE, S., MORCK DW, LUCAS ML, BURET AG (2013). Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis. Antimicrob. Ag. Chemother. 57(3): 1385-1393

BURET, A.,G., BHARGAVA, A. (2013) Modulatory mechanisms of enterocyte apoptosis by viral, bacterial, and parasitic pathogens. Critical Rev. in Microbiology (in press).

O’HARA, J.R., FEENER, T.D, FISCHER, C.D., BURET , A.G. (2012) Campylobacter jejuni disrupts protective TLR9 signaling in colonic epithelial cells and increases the severity of DSS-induced colitis in mice. Infect. Immun. 80(4):1563-1571

LAPOINTE, T.K., BURET, A.G. (2012) Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without alerting epithelial permeability. Am. J. Physiol. (Gastrointestinal Liver Physiol) 302(3):G343-G351

O’CONNOR PM, LAPOINTE TK, JACKSON S, BECK PB, JONES, N.L., BURET AG. (2011) H. pylori activates calpain via TOLL-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells. Infect. Immun 79(10): 3887-3894.

COTTON J, BEATTY J, BURET A.G. (2011) Host-parasite interactions in giardiasis. Int. J. Parasitol. (41):925-933.

FLYNN, A.N., WANG, A., McKAY, D.M., BURET, A.G. (2011) Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli. Can. J. Physiol. Pharmacol. 89(2):143-148.            

FISHER C, BEATTY JK, ZVAIGNE, CG, MORCK DW, LUCAS ML, BURET AG. (2011) Tulathromycin inhibits NFkB signaling via the induction of caspase-3-dependent apoptosis in bovine neutrophils. Antimicr. Ag. Chemother. 55(1); 338-348.

Sproule-Willoughby, K.M., Stanton, M.M., Rioux, K. P. , McKay, D. M., Buret, A. G., Ceri, H. (2010)  In vitro anaerobic biofilms of human colonic microbiota. J Microbiol Methods 83:296-301.

Lapointe, T.K., O’Connor, P.M., Jones, N.L., Menard, D., Buret, A.G. (2010) Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter pylori infection. Cell. Micro. 12(5): 692-703. BURET, A.G. (2010) Immuno-modulation and anti-inflammatory benefits of antibiotics: The example of tilmicosin. Can. J. Vet Res. 74;1:1-10

KALISCHUK, L.D., BURET, A.G. (2010) A role for Campylobacter-jejuni induced enteritis in inflammatory bowel disease? Am. J. Physiol. 298:G1-G9 

Kalischuk, L.D., inglis, g.d., BURET.A.G.  (2009) C. jejuni induces transcellular translocation of commensal bacteria via lipid rafts. Gut Pathog. 1;2:1-10.

LAMB-ROSTESKI , J.M., KALISCHUK, L.D., INGLIS, G.D., BURET, A.G. (2008) Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation. Infect. Immun. 76;8:3390-3398

YU, L.C.H., HUANG, C-Y, KUO, W-T, SAYER, H., TURNER, J.R., BURET, A.G. (2008) SGLT-1 –mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis –induced apoptosis. Int. J. Parasitol. 38: 923-934.

BURET A.G. (2008) Pathophysiology of enteric infections with Giardia duodenalis. Parasite 15:261-266

YU, L.C.H., TURNER, J.R., BURET, A.G. (2006). LPS/CD14 activation triggers SGLT-1 –mediated glucose uptake and cell rescue in enterocytes via early apoptotic pathways upstream of caspase-3. Exp. Cell Res. 312(17):3276-3286

CHIN, A.C., FLYNN, A.N., FEDWICK, J.P., BURET, A.G. (2006) The role of caspase-3 in lipopolysaccharide-mediated disruption of epithelial tight junctions. Can J Physiol Pharmacol. 84(10):1043-1050.

WALLACE, J.L., BURET, A.G. (2006)  GI-sparing anti-inflammatory drugs: A promising future         . Gastroenterol. Hepatol. Ann. Rev. 1:123-127

FEDWICK, J.P., LAPOINTE, T.K., MEDDINGS, J.B., SHERMAN, P.M., BURET, A.G. (2005) Helicobacter pylori activates myosin light chain kinase and disrupts claudins –4 and -5 to increase epithelial permeability in a strain-dependent fashion. Infect. Immun. 73(12);7844-7852.

YU, L.C.H., FLYNN, A.N., TURNER, J.R., BURET, A.G. (2005) SGLT-1 mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: A novel cellular rescue mechanism?  FASEB J. 19: 1822-1835 

SIGALET,D.L., MARTIN, G.R., BUTZNER, D., BURET, A.G., MEDDINGS, J. (2005) A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome. J. Ped. Surgery 40(5):763-768

NERLAND, E.M., LEBLANC, J.M., FEDWICK, J.P., MORCK, D.W., MERRILL, J.K., DICK, P., PARADIS, M.A., BURET, A.G. (2005) Oral Tilmicosin induces leukocyte apoptosis, reduces Leukotriene B4, and attenuates inflammation in the Actinobacillus pleuropneumoniae-Infected Porcine Lung. Am. J. Vet Res. 66(1):100-107. 

SCOTT, K.G.E., YU, L.C.H., BURET, A.G. (2004) The role of CD8+ and CD4+ T lymphocytes in jejunal mucosal injury during murine giardiasis. Infect. Immun. 72(6):3536-3542. 

CHIN, A.C., VERGNOLLE, N., MACNAUGHTON, W.K., WALLACE, J.L., HOLLENBERG, M.D., BURET, A.G. (2003) Proteinase-activated receptor-1 activation induces epithelial apoptosis and increases intestinal permeability. Proc. Nat. Acad. Sc. 100:11104-11109

SELECTED Publications (From 2016 to 2019)

MOTTA JP, DENADAI-SOUZA A, SAGNAT D, GUIRAUD L, BONNART C, SEBBAG M, ROUSSET P, LAPEYRE A, SEGUY C, GALIPEAU HJ, BONNET D, ALRIC L, VERDU E, BURET AG, WALLACE JL, HOLLENBERG M, OSWALD E, SERINO M, DERAISON C, VERGNOLLE N. (2019) Active thrombin is produced by intestinal epithelium to control mucosal biofilm. Nat. Comm. (2019; in press)

MANKO, A., THIBAULT A, MOTTA JP, COTTON JA, FEENER TD, OYEYEMI A, BINDRA S, VALLANCE BA, WALLACE JL, BURET AG. (2019) Role of the NLRP3 inflammasome in the protective effects of Giardia during co-infection with enteropathogenic Escherichia coli. Infect. Immun. (submitted)

WALLACE, J.L., NAGY, P., FEENER, T.D., ALLAIN, T., DITROI, T., VAUGNAN, D..C, MUSCARA, M.N., DE NUCCI, G., BURET, A.G. (2019) A proof-of-concept, Phase 2 clinical trial of the gastrointestinal safety of a Hydrogen Sulfide-releasing anti-inflammatory drug. Br. J. Pharmacol. doi: 10.1111/bph.14641

BURET AG, MOTTA JP, ALLAIN T, FERRAZ J, WALLACE JL. (2019) Pathobiont release from dysbiotic microbiota biofilms in intestinal inflammatory diseases: A role for iron?. Journal of Biomedical Science 26:1 (2019) https://doi.org/10.1186/s12929-018-0495-4

MOTTA JP, ALLAIN T, GREEN-HARRISON L, GROVES RA, FEENER T, RAMAY H, BECK PL, LEWIS IA, WALLACE JL, BURET AG. (2018) Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease. Inflam. Bowel Dis. 24 (7): 1493-1502

Featured in UToday, June 2018, and on radio interview with 770 CHQR (Global News)

MOGES, R., DESMONTS DE LAMACHE D., SAJEDY, S., RENAUX B.S., HOLLENBERG, M.D., MUENCH, G., ABBOTT E.M., BURET, A.G. (2018) Anti-inflammatory effects of antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and inhibits pro-inflammatory CXCL-8, IL1a and LTB4 production, while inducing the release of pro-resolving Lipoxin A4 and Resolvin D­1. Front. Vet. Sci (Vet. Pharmacol. Toxicol.). 5: 57-67

ALLAIN, T., CHAOUCH,S., THOMAS, M., VALLEE, I., BURET, A.G., LANGELLA, P. GRELLIER, P., POLACK, B.,M BERMUDEZ-HUMARAN, L.G., FLORENT, I. (2018) Bile-Salt-Hydrolases from the probiotic strain Lactobacillus johnsonii La1 mediate anti-giardial activity in vitro and in vivo. Front. Microbiol. (January) 8:2707  https://doi.org/10.3389/fmicb.2017.02707

WALLACE JL , MOTTA, JP, BURET, AG. (2018) Hydrogen Sulfide: An Agent of Stability at the Microbiome-Mucosa Interface. Am. J. Physiol.  314: G143-G149 DOI: 10.1152/ajpgi.00249.2017

GERBABA, T.K., BURET, A.G. (2017) Modeling Host-microbiome Interactions in Caenorhabditis elegans. J. Nemadotol. 49(4):348-356

AMAT C.B., MOTTA J-P, FEKETE E., MOREAU F., CHADEE K., BURET A.G. (2017) Cysteine protease-dependent mucus disruptions and differential mucin gene expression in Giardia duodenalis infection. Am. J. Pathol. 187(11);2486-2498

MANKO A, MOTTA J-P, COTTON JA, FEENER T.D., OYEYEMI A., VALLANCE B.A.,, WALLACE J.L., BURET A.G. (2017) Giardia Co-Infection Promotes the Secretion of Antimicrobial Peptide Beta-defensin 2 and Trefoil Factor 3 and Attenuates Attaching and Effacing Bacteria-induces Intestinal Disease. PLoS ONE 12(6); e0178647

ALLAIN, T., AMAT, C.B., MOTTA, J-P., MANKO, A., BURET, A.G. (2017) Interactions of Giardia sp. with the intestinal barrier: epithelium, mucus, and microbiota. Tissue Barriers 5(1): e1274354.

BEATTY, JK, AKIERMAN, SV, MOTTA, JP, MUISE, S, BHARGAVAA, BECK, PL, RIOUX, KP, MCKNIGHT, GW, WALLACE, JL, BURET, AG. (2017) Giardia duodenalis-induced pathogenic dysbiosis of human intestinal microbiota biofilms. Int. J. Parasitol.  47(6): 311-326

Selected for cover illustration

HALLIEZ, M., MOTTA, JP., FEENER, T., GUERIN, G., LEGOFF, L., FRANCOIS, A., COLASSE, E., FAVENNEC, L., GARGALA, G., LAPOINTE, T., ALTIER, C. BURET, AG. (2016) Giardia duodenalis induces bacterial translocation and causes post-infectious visceral hypersensitivity. Am J Physiol (Gastrointestinal and Liver Physiology) 310(8): G574-G585 DOI: 10.1152/ajpgi.00144.2015

Degrees

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