University of Calgary

Elmar Josef Prenner

  • Professor
  • Biochemistry

Research Interests

Biomembrane architecture (lipid rafts, domains), lipid-protein interactions, nanoparticle based pulmonary drug delivery; bioinorganic chemistry (membrane interactions of heavy metals); bioanalytical chemistry (bioassay development), biophysical techniques.

Graduate Students

Lai, Patrick Ph.D. Nanoparticle based pulmonary drug delivery
Mahadeo, Mark  Ph.D. Impact of lipid based anticancer drugs on membrane architecture
Patterson, Matthew M.Sc. Lipid-protein interactions in tear film model systems
Weiam Daear  MSc Nanoparticle synthesis and characterization
Evan Kerek  MSc

Membrane interactions of toxic metals

     
Chiu, Michael MD-MSc Membrane interactions of antimicrobial peptides

Awards

2006 - Poster prize by the Petroleum Tech Alliance of Canada for the 'most innovative water-related technology'
2002 - AHFMR Scholar award grant

 

Selected Publications

  • Google Scholar Link
  • T. Abraham, E.J. Prenner, R.N.A.H. Lewis, C.T. Manz, R.S. Hodges and R.N. McElhaney Structure-Activity Relationships of the Antimicrobial Peptide Gramicidin S and its Analogues: Aqueous Solubility, Self Association, Conformation, Antimicrobial Activity and Interaction with  Lipid Bilayer Model Membranes Biochim. Biophys. Acta 1838 (2014) 1420-142 
  • M.T. Le, M. Hassanin, M. Mahadeo, J. Gailer, E.J. Prenner Hg- and Cd-induced modulation of lipid packing and monolayer fluidity in biomimetic erythrocyte model systems. Chemistry and Physics of Lipids 170– 171 (2013) 46– 54 
  • S. Nathoo, J.K. Litzenberger, D. Bay, R.J. Turner, and E.J. Prenner* Visualizing a multidrug resistance protein, EmrE, with major bacterial lipids using Brewster angle microscopy Chem Phys Lipids 167– 168 (2013) 33– 42 
  • T. Gröger, S. Nathoo, T. Ku, C. Sikora, R. J. Turner and E. J. Prenner* Real-time imaging of lipid domains and distinct coexisting membrane protein clusters Chem. Phys. Lipids 165 (2012) 216-224 
  • M. H. Chiu and E. J. Prenner* Differential scanning calorimetry: an invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions. J. Pharm. BioAllied Sciences 3 (2011) 39-59 (invited review)
  • S. Nathoo, J.K. Litzenberger, D. Bay, R.J. Turner, and E.J. Prenner Visualizing a multidrug resistance protein, EmrE, with major bacterial lipids using Brewster angle microscopy Chem Phys Lipids 167– 168 (2013) 33– 42 
  • T. Gröger, S. Nathoo, T. Ku, C. Sikora, R. J. Turner and E. J. Prenner* Real-time imaging of lipid domains and distinct coexisting membrane protein clusters Chem. Phys. Lipids 165 (2012) 216-224 
  • M. H. Chiu and E. J. Prenner* Differential scanning calorimetry: an invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions. J. Pharm. BioAllied Sciences 3 (2011) 39-59 (invited review) 
  • P. Lai, S. Nathoo, T. Ku, S. Gill, S. Azarmi, W. Roa, R. Löbenberg and E.J. Prenner. Real-time imaging of interactions between dipalmitoylphosphatidylcholine monolayers and gelatin based nanoparticles using Brewster Angle Microscopy. J Biol Nanotech 6 (2010), 1-8 
  • E. F. Haney, S. Nathoo, H. J. Vogel and E. J. Prenner. Induction of non-lamellar lipid phases by antimicrobial peptides: A possible link to mode of action? Chem. Phys. Lipids 163 (2010) 82–93
  • M. H Chiu, C.-P. L. Wan, P. M.M. Weers and E. J. Prenner. Apolipophorin III Interaction with Model Membranes Composed of Phosphatidylcholine and Sphingomyelin using Differential Scanning Calorimetry Biochim. Biophys Acta 1788 (2009) 2160–2168
  • M.T. Le, J. Gailer and E. J. Prenner. Hg++ and Cd++ interact differently with biomimetic erythrocyte membranes Biometals 22 (2009) 261-274
  • T. Ku, S. Gill, R. Löbenberg, S. Azarmi, W. Roa and E. J. Prenner. Size Dependent Interactions of Nanoparticles with Lung Surfactant Model Systems and the Significant Impact on Surface Potential. J Nanosci Nanotech 8 (2008) 2971-2978
  • V.V. Andrushchenko, M.H. Aarabi, L.T. Nguyen, E.J. Prenner and H.J. Vogel. Thermodynamics of the Interactions of Tryptophan-Rich Cathelicidin Antimicrobial Peptides with Model and Natural Membranes Biochim. Biophys. Acta 1778 (2008) 1004-1014
  • V.V. Andrushchenko, H.J. Vogel and E.J. Prenner. Interactions of Tryptophan-Rich Cathelicidin Antimicrobial Peptides with Model Membranes Studied by Differential Scanning Calorimetry. Biochim. Biophys. Acta 1768 (2007) 2447-2458
  • S. Gill, R. Loebenberg, T. Ku, S. Arzami, W. Roa and E. J. Prenner. Nanoparticles: Characteristics, Mechanisms of Action and Toxicity in Pulmonary Drug Delivery-A Review. J Biomed Nanotech. 2 (2007) 107-119
  • E.J. Prenner, G. Honsek, D. Hönig, D. Möbius and K. Lohner. Biophysical investigations and imaging of the lateral organization of sphingomyelin and phosphatidylcholine monolayers. Chem. Phys. Lipids 145 (2007) 106-118

Degrees

  • PhD - Technical Chemistry
    University of Technology Graz, 1993
  • Dipl-Ing - Technical Chemistry
    University of Technology Graz, 1988
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