University of Calgary

Andre Buret

  • Professor
  • Professor
  • Integrative Cell Biology

Research Interests

Similar inflammatory, immunologic, and pathophysiologic events characterize disease processes at mucosal sites such as the intestine and the lung. Critical issues to this research area include understanding the role of immune cells and mediators in the production of disease. The overall aim of my research is to define microbial-epithelial and immune cell interactions in these systems, and how such interactions may affect gastrointestinal and pulmonary physiology, responsiveness, and inflammation, in an attempt to develop novel therapeutic strategies.

Graduate Students

Amat, Christina MSc Effects of Giardia on intestinal mucins

Awards

2013: Honorary Professorship, free Old Herborn University (Germany)
2013: Inducted a member of the Order of the University of Calgary (“to recognize exemplary service to the university and the community (local, provincial, and international), international stature as a scientist, and award-winning teaching”).
2012: Honoured Athletic Leadership Award (karate), City of Calgary Booster Club
2012: Killam Annual Professor Research Award
2012: NSERC CREATE award 
2011: Faculty of Science Award for Excellence in Research, University of Calgary
2008: Robert A. Wardle Medal, Canadian Society of Zoologists, for outstanding contributions to Parasitology research on the national and international scenes
2008: Endeavour Research Fellowship Award, Government of Australia, for research and innovation
2007: Research Excellence Award, Canadian Association of Gastroenterologists
2007: Synergy Award for collaborative research and innovation, Natural Sciences and Engineering Research Council of Canada (NSERC) 
2007 - Research Excellence Award, Canadian Association of Gastroenterology
2006 - NSERC Synergy Award for collaborative research and innovation, Univ. of Calgary nominee
2005 - Students' Union Teaching Excellence Award Honorable Mention Winner
2003 - University of Calgary Graduate Students' Association Teaching Excellence

Selected Publications

  • Google Scholar Link

  • FISHER C, BEATTY JK, DUQUETTE, S., MORCK DW, LUCAS ML, BURET AG (2013). Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis. Antimicrob. Ag. Chemother. 57(3): 1385-1393

  • BURET, A.,G., BHARGAVA, A. (2013) Modulatory mechanisms of enterocyte apoptosis by viral, bacterial, and parasitic pathogens. Critical Rev. in Microbiology (in press).

  • O’HARA, J.R., FEENER, T.D, FISCHER, C.D., BURET , A.G. (2012) Campylobacter jejuni disrupts protective TLR9 signaling in colonic epithelial cells and increases the severity of DSS-induced colitis in mice. Infect. Immun. 80(4):1563-1571

  • LAPOINTE, T.K., BURET, A.G. (2012) Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without alerting epithelial permeability. Am. J. Physiol. (Gastrointestinal Liver Physiol) 302(3):G343-G351

  • O’CONNOR PM, LAPOINTE TK, JACKSON S, BECK PB, JONES, N.L., BURET AG. (2011) H. pylori activates calpain via TOLL-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells. Infect. Immun 79(10): 3887-3894.

  • COTTON J, BEATTY J, BURET A.G. (2011) Host-parasite interactions in giardiasis. Int. J. Parasitol. (41):925-933.

  • FLYNN, A.N., WANG, A., McKAY, D.M., BURET, A.G. (2011) Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli. Can. J. Physiol. Pharmacol. 89(2):143-148.            

  • FISHER C, BEATTY JK, ZVAIGNE, CG, MORCK DW, LUCAS ML, BURET AG. (2011) Tulathromycin inhibits NFkB signaling via the induction of caspase-3-dependent apoptosis in bovine neutrophils. Antimicr. Ag. Chemother. 55(1); 338-348.

  • Sproule-Willoughby, K.M., Stanton, M.M., Rioux, K. P. , McKay, D. M., Buret, A. G., CeriH. (2010)  In vitro anaerobic biofilms of human colonic microbiota. J Microbiol Methods 83:296-301.

  • Lapointe, T.K., O’Connor, P.M., Jones, N.L., Menard, D., Buret, A.G. (2010) Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter pylori infection. Cell. Micro. 12(5): 692-703. 

  • BURET, A.G. (2010) Immuno-modulation and anti-inflammatory benefits of antibiotics: The example of tilmicosin. Can. J. Vet Res. 74;1:1-10

  • KALISCHUK, L.D., BURET, A.G. (2010) A role for Campylobacter-jejuni induced enteritis in inflammatory bowel disease? Am. J. Physiol. 298:G1-G9 

  • Kalischuk, L.D., inglis, g.d., BURET.A.G.  (2009) C. jejuni induces transcellular translocation of commensal bacteria via lipid rafts. Gut Pathog. 1;2:1-10.

  • LAMB-ROSTESKI , J.M., KALISCHUK, L.D., INGLIS, G.D., BURET, A.G. (2008) Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation. Infect. Immun. 76;8:3390-3398

  • YU, L.C.H., HUANG, C-Y, KUO, W-T, SAYER, H., TURNER, J.R., BURET, A.G. (2008) SGLT-1 –mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis –induced apoptosis. Int. J. Parasitol. 38: 923-934.

  • BURET A.G. (2008) Pathophysiology of enteric infections with Giardia duodenalis. Parasite 15:261-266

  • YU, L.C.H., TURNER, J.R., BURET, A.G. (2006). LPS/CD14 activation triggers SGLT-1 –mediated glucose uptake and cell rescue in enterocytes via early apoptotic pathways upstream of caspase-3. Exp. Cell Res. 312(17):3276-3286

  • CHIN, A.C., FLYNN, A.N., FEDWICK, J.P., BURET, A.G. (2006) The role of caspase-3 in lipopolysaccharide-mediated disruption of epithelial tight junctions. Can J Physiol Pharmacol. 84(10):1043-1050.

  • WALLACE, J.L., BURET, A.G. (2006)  GI-sparing anti-inflammatory drugs: A promising future         . Gastroenterol. Hepatol. Ann. Rev. 1:123-127

  • FEDWICK, J.P., LAPOINTE, T.K., MEDDINGS, J.B., SHERMAN, P.M., BURET, A.G(2005) Helicobacter pylori activates myosin light chain kinase and disrupts claudins –4 and -5 to increase epithelial permeability in a strain-dependent fashion. Infect. Immun. 73(12);7844-7852.

  • YU, L.C.H., FLYNN, A.N., TURNER, J.R., BURET, A.G. (2005) SGLT-1 mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: A novel cellular rescue mechanism?  FASEB J. 19: 1822-1835

     

  • SIGALET,D.L., MARTIN, G.R., BUTZNER, D., BURET, A.G., MEDDINGS, J. (2005) A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome. J. Ped. Surgery 40(5):763-768

  • NERLAND, E.M., LEBLANC, J.M., FEDWICK, J.P., MORCK, D.W., MERRILL, J.K., DICK, P., PARADIS, M.A., BURET, A.G. (2005) Oral Tilmicosin induces leukocyte apoptosis, reduces Leukotriene B4, and attenuates inflammation in the Actinobacillus pleuropneumoniae-Infected Porcine Lung. Am. J. Vet Res. 66(1):100-107. 

  • SCOTT, K.G.E., YU, L.C.H., BURET, A.G. (2004) The role of CD8+ and CD4+ T lymphocytes in jejunal mucosal injury during murine giardiasis. Infect. Immun. 72(6):3536-3542. 

  • CHIN, A.C., VERGNOLLE, N., MACNAUGHTON, W.K., WALLACE, J.L., HOLLENBERG, M.D., BURET, A.G. (2003) Proteinase-activated receptor-1 activation induces epithelial apoptosis and increases intestinal permeability. Proc. Nat. Acad. Sc. 100:11104-11109

Degrees

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