Research Interests

• Cellular and molecular mechanisms of neuronal aging and neurodegeneration.
• Neuromodulatory actions of adhesion molecules and their receptors.
• Regeneration of the nervous system.

Courses Taught F09-W10

Graduate Students

Selected publications

• Hermann PM, Diep CQ, Nicol JJ, Bulloch AGM, Wildering WC. (2005) Biphasic effects of RGD-peptides on peripheral nerve regeneration and endoneurial phagocyte activation.
• Hermann PM, Nicol JJ, Nagle GT, Bulloch AGM, Wildering WC. (2005) Epidermal growth factor dependent enhancement of axonal regeneration in the pond snail Lymnaea stagnalis: Role of phagocyte survival. J Comp Neurol. (in press).
• Pollock NS, Atkinson-Leadbeater K, Johnston J, Larouche M, Wildering WC, McFarlane S. (2005) Voltage-gated potassium channels regulate the response of retinal growth cones to axon extension and guidance cues. Eur J Neurosci. 22(3):569-578.
• Hermann PM, Schein CH, Nagle GT, Wildering WC. (2004) Lymnaea EGF and Gigantoxin I, novel invertebrate members of the epidermal growth factor family. Curr Pharm Design 10(31): 3885-3892.
• Wildering WC, Hermann PM, Bulloch AGM. (2002) Rapid neuromodulatory actions of integrin ligands. J Neurosci 22(7): 2419-2426.Wildering WC, Hermann PM, Bulloch AGM. (2001). Lymnaea epidermal growth factor promotes axonal regeneration. J Neurosci 21(23): 9345-9354.
• Hermann PM, van Kesteren RE, Wildering WC, Painter SD, Reno J, Smit JS, Kumar SB, Geraerts WPM, Ericsson LH, Smit AB, Bulloch AGM, Nagle GT. (2000) Neurotrophic actions of a novel molluscan epidermal growth factor. J Neurosci 20(17): 6355-6364.
• Hermann PM, Wildering WC, Bulloch AGM. (2000) Functional recovery of respiratory behavior during axonal regeneration in snails (Lymnaea stagnalis) is experience dependent. Behav Neurosci 114(2): 410-423.
• Wildering, W.C., Hermann, P.M. and Bulloch, A.G.M. (1998) Neurite outgrowth, RGD-dependent, and RGD-independent adhesion of identified molluscan motoneurons on selected substrates. J. Neurobiol. 35(1): 37-52.
• Hermann PM, Lukowiak K, Wildering WC, Bulloch AGM. (1997) Pronase acutely modifies HVA Ca2+ current and integrative properties of Lymnaea neurons. Eur J Neurosci 9(12): 2624-2633.
• Fainzilber M, Smit AB, Syed NI, Wildering WC, Hermann PM, van der Schors RC, Jiménez C, Li KW, van Minnen J, Bulloch AGM, Ibáñez CF, Geraerts WPM. (1996) CRNF, a molluscan neurotrophic factor that interacts with the p75 neurotrophin receptor. Science 274: 1540-1543.
• Lukowiak K, Ringseis E, Spencer G, Wildering WC, Syed NI. (1996) Operant conditioning of aerial respiratory behaviour in Lymnaea stagnalis. J exp Biol 199, 683-691.
• Wildering WC, Lodder JC, Kits KS, Bulloch AGM. (1995) Nerve Growth Factor (NGF) acutely enhances high-voltage-activated calcium currents in molluscan neurons. J Neurophysiol 74, 2778-2781.
• Jimenez CR, van Veelen PA, Li KW, Wildering WC, Geraerts WP, Tjaden UR, van der Greef J. (1994) Neuropeptide expression and processing as revealed by direct matrix-assisted laser desorption ionization mass spectrometry of single neurons. J Neurochem. 62(1):404-407.
• Van Veelen PA, Jiménez CR, Li KW, Wildering WC, Geraerts WP, Tjaden UR, van der Greef J. (1994) New advanced tools in peptide/protein research: matrix-assisted laser desorption ionization mass spectrometry. J. Contr. Release 29: 223-229.
• Van Veelen PA, Jiménez CR, Li KW, Wildering WC, Geraerts WP, Tjaden UR, van der Greef J. (1993) Direct peptide profiling of single neurons by matrix-assisted laser desorption ionization mass spectrometry. Org. Mass Spectrom. 28: 1542-1547.
• Wildering WC, Janse C. (1992) Serotonergic modulation of junctional conductance in an identified pair of neurons in the mollusc Lymnaea stagnalis. Brain Res 595, 343-352.
• De Vlieger TA, Wildering WC, van der Wilt GJ, Janse C. (1992) The role of membrane properties, synaptic input and electrical junction in determination of spike output of a pair of peptidergic neurons in the mollusc Lymnaea stagnalis. Acta Biol Hung 43, 137-146.
• Wildering WC, van der Roest M, de Vlieger TA, Janse C. (1991) Age-related changes in junctional and non-junctional conductances in two electrically coupled peptidergic neurons of the mollusc Lymnaea stagnalis. Brain Res 547, 89-98.
• Wildering WC, Janse C, de Vlieger TA. (1991) The role of pacemaker properties and synaptic input in generation and modulation of spiking activity in a pair of electrically coupled peptidergic neurons. Brain Res 556, 324-328.
• Janse C, Wildering WC, Popelier CM. (1989) Age-related changes in female reproductive activity and growth in the mollusc Lymnaea stagnalis. J Gerontol 44, b148-b155.